Plan treatment around your patients’ lives

Once you’ve chosen dosing that fits your patient’s needs and preferences, it’s time to select administration options—such as prefilled syringes—and initiate therapy.

Plan treatment around your patients’ lives

Once you’ve chosen dosing that fits your patient’s needs and preferences, it’s time to select administration options—such as prefilled syringes—and initiate therapy.

See how simple self-administration can be with Hizentra

Self-infusing with Hizentra prefilled syringes

Download our step-by-step guide to pump administration

Self-infusing with Hizentra vials

Why dosing flexibility matters for patients

Initiating Hizentra therapy for PI

Before switching to Hizentra, obtain the patient’s serum IgG trough level to guide subsequent dose adjustments.

Weekly

Biweekly (every 2 weeks)

Frequent dosing (2 to 7 times per week)

Start Hizentra 1 week after last Intravenous Immune Globulin (Human) (IVIg) infusion.

Initial weekly dose = (Previous IVIg dose [in grams]/No. of weeks between IVIg doses) X 1.37

Start Hizentra 1 or 2 weeks after last IVIg infusion or 1 week after the last weekly SCIg infusion.

Administer twice the calculated weekly dose.

Start Hizentra 1 week after last IVIg or SCIg infusion.

Divide the calculated weekly dose by the desired number of times per week.

Adjust the dose based on clinical response and serum IgG trough levels.

Choosing volume and rate for self-administration

Infusion Parameters*

1st Infusion

Subsequent Infusions

Pump

Volume (g/site)

Rate (g/hr/site)

≤3

≤5

Choosing volume and rate for self-administration

Infusion Parameters*

1st Infusion

Subsequent Infusions

Pump

Volume (g/site)

Rate (g/hr/site)

≤3

≤5

*As tolerated.

Administering Hizentra therapy

Hizentra should be administered subcutaneously (SC) only. Do not administer intravenously. Hizentra can be dosed daily up to every 2 weeks for PI using an infusion pump and relatively small needle(s).

Recommended Infusion Sites

A Hizentra dose may be infused into multiple injection sites. Use up to 8 sites simultaneously per infusion. More than one infusion device can be used. Infusion sites should be at least 2 inches apart. Change the actual site of infusion with each administration
SC needles are smaller than IV needles. Depending on a patient’s size and weight, a needle as short as 4 mm or as long as 14 mm can be used.

Dosing

Explore tools and information to help you tailor treatment to individual patient needs

Dosing calculator

SHARE Nurse Training program

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Managing infusions

Information and resources are available to help patients manage their ongoing administration of Hizentra

Managing therapy

Plan treatment around your patients’ lives

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Plan treatment around your patients’ lives

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See how simple self-administration can be with Hizentra

Initiating Hizentra therapy for PI

Choosing volume and rate for self-administration

Choosing volume and rate for self-administration

Administering Hizentra therapy

Recommended Infusion Sites

Dosing

SHARE Nurse Training program

Managing infusions