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or:#0e3559;background-color:var(--c-blue-700)}.text-blue-700{color:#0e3559;color:var(--c-blue-700)}.bg-blue-700-at-95{background-color:#0e3559f2;background-color:var(--c-blue-700-at-95)}.text-blue-700-at-95{color:#0e3559f2;color:var(--c-blue-700-at-95)}.bg-blue-800{background-color:#0b2945;background-color:var(--c-blue-800)}.text-blue-800{color:#0b2945;color:var(--c-blue-800)}.bg-blue-900{background-color:#081f35;background-color:var(--c-blue-900)}.text-blue-900{color:#081f35;color:var(--c-blue-900)}.bg-red-50{background-color:#f2e6eb;background-color:var(--c-red-50)}.text-red-50{color:#f2e6eb;color:var(--c-red-50)}.bg-red-100{background-color:#d5b0bf;background-color:var(--c-red-100)}.text-red-100{color:#d5b0bf;color:var(--c-red-100)}.bg-red-200{background-color:#c18aa1;background-color:var(--c-red-200)}.text-red-200{color:#c18aa1;color:var(--c-red-200)}.bg-red-300{background-color:#a55476;background-color:var(--c-red-300)}.text-red-300{color:#a55476;color:var(--c-red-300)}.bg-red-400{background-color:#93335b;background-color:var(--c-red-400)}.text-red-400{color:#93335b;color:var(--c-red-400)}.bg-red-500{background-color:#780032;background-color:var(--c-red-500)}.text-red-500{color:#780032;color:var(--c-red-500)}.bg-red-500-at-95{background-color:#780032f2;background-color:var(--c-red-500-at-95)}.text-red-500-at-95{color:#780032f2;color:var(--c-red-500-at-95)}.bg-red-500-moa{background-color:#690730e8;background-color:var(--c-red-500-moa)}.text-red-500-moa{color:#690730e8;color:var(--c-red-500-moa)}.bg-red-600{background-color:#6d002e;background-color:var(--c-red-600)}.text-red-600{color:#6d002e;color:var(--c-red-600)}.bg-red-700{background-color:#550024;background-color:var(--c-red-700)}.text-red-700{color:#550024;color:var(--c-red-700)}.bg-red-800{background-color:#42001c;background-color:var(--c-red-800)}.text-red-800{color:#42001c;color:var(--c-red-800)}.bg-red-900{background-color:#320015;background-color:var(--c-red-900)}.text-red-900{color:#320015;color:var(--c-red-900)}.bg-red-moa{background-color:#7c0e43;background-color:var(--c-red-moa)}.text-red-moa{color:#7c0e43;color:var(--c-red-moa)}.bg-light-blue-50{background-color:#fbfcfd;background-color:var(--c-light-blue-50)}.text-light-blue-50{color:#fbfcfd;color:var(--c-light-blue-50)}.bg-light-blue-100{background-color:#f1f5f9;background-color:var(--c-light-blue-100)}.text-light-blue-100{color:#f1f5f9;color:var(--c-light-blue-100)}.bg-light-blue-200{background-color:#eaf0f7;background-color:var(--c-light-blue-200)}.text-light-blue-200{color:#eaf0f7;color:var(--c-light-blue-200)}.bg-light-blue-300{background-color:#e1eaf3;background-color:var(--c-light-blue-300)}.text-light-blue-300{color:#e1eaf3;color:var(--c-light-blue-300)}.bg-light-blue-400{background-color:#dbe5f1;background-color:var(--c-light-blue-400)}.text-light-blue-400{color:#dbe5f1;color:var(--c-light-blue-400)}.bg-light-blue-500{background-color:#d2dfed;background-color:var(--c-light-blue-500)}.text-light-blue-500{color:#d2dfed;color:var(--c-light-blue-500)}.bg-light-blue-600{background-color:#bfcbd8;background-color:var(--c-light-blue-600)}.text-light-blue-600{color:#bfcbd8;color:var(--c-light-blue-600)}.bg-light-blue-700{background-color:#959ea8;background-color:var(--c-light-blue-700)}.text-light-blue-700{color:#959ea8;color:var(--c-light-blue-700)}.bg-light-blue-800{background-color:#747b82;background-color:var(--c-light-blue-800)}.text-light-blue-800{color:#747b82;color:var(--c-light-blue-800)}.bg-light-blue-900{background-color:#585e64;background-color:var(--c-light-blue-900)}.text-light-blue-900{color:#585e64;color:var(--c-light-blue-900)}.bg-light-blue-moa{background-color:#4071a0;background-color:var(--c-light-blue-moa)}.text-light-blue-moa{color:#4071a0;color:var(--c-light-blue-moa)}.bg-shadow-gray{background-color:#4f4c4d15;background-color:var(--c-shadow-gray)}.text-shadow-gray{color:#4f4c4d15;color:var(--c-shadow-gray)}.bg-dark-gray{background-color:#262626;background-color:var(--c-dark-gray)}.text-dark-gray{color:#262626;color:var(--c-dark-gray)}.bg-orange-50{background-color:#fff5e8;background-color:var(--c-orange-50)}.text-orange-50{color:#fff5e8;color:var(--c-orange-50)}.bg-orange-100{background-color:#ffe1b9;background-color:var(--c-orange-100)}.text-orange-100{color:#ffe1b9;color:var(--c-orange-100)}.bg-orange-200{background-color:#ffd397;background-color:var(--c-orange-200)}.text-orange-200{color:#ffd397;color:var(--c-orange-200)}.bg-orange-300{background-color:#ffbf67;background-color:var(--c-orange-300)}.text-orange-300{color:#ffbf67;color:var(--c-orange-300)}.bg-orange-400{background-color:#ffb249;background-color:var(--c-orange-400)}.text-orange-400{color:#ffb249;color:var(--c-orange-400)}.bg-orange-500{background-color:#ff9f1c;background-color:var(--c-orange-500)}.text-orange-500{color:#ff9f1c;color:var(--c-orange-500)}.bg-orange-600{background-color:#e89119;background-color:var(--c-orange-600)}.text-orange-600{color:#e89119;color:var(--c-orange-600)}.bg-orange-70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8.34%,#0b2945 61.06%);background:var(--c-gradient-blue)}.bg-gradient-blue-radial{background:radial-gradient(191.97% 130.18% at 50.06% 50%,#174a7c 0,#3d001a);background:var(--c-gradient-blue-radial)}.bg-gradient-red{background:linear-gradient(262deg,#780032 8.34%,#42001c 61.06%);background:var(--c-gradient-red)}.bg-gradient-red-radial{background:radial-gradient(circle,#000 0,#870038 0,#000);background:var(--c-gradient-red-radial)}.bg-gradient-nav{background:linear-gradient(0deg,#eae7e426,#eae7e426),linear-gradient(0deg,#020e1a00,#020e1a),#051f396e;background:var(--c-gradient-nav)}.bg-gradient-purple-blue{background:radial-gradient(191.97% 130.18% at 50.06% 50%,#174a7c 0,#3d001a);background:var(--c-gradient-purple-blue)}.bg-gradient-purple-blue-linear{background:linear-gradient(91deg,#780032 -2.57%,#174a7c 118.43%);background:var(--c-gradient-purple-blue-linear)}.bg-gradient-blue-red{background:linear-gradient(180deg,#174a7c -43.22%,#780032);background:var(--c-gradient-blue-red)}.bg-gradient-blue-purple-linear{background:linear-gradient(257deg,#780032 0,#144a7d 71.91%,#550024 114.72%);background:var(--c-gradient-blue-purple-linear)}.bg-button-brand{background-color:linear-gradient(262deg,#780032 8.34%,#42001c 61.06%);background-color:var(--c-button-brand)}.text-button-brand{color:linear-gradient(262deg,#780032 8.34%,#42001c 61.06%);color:var(--c-button-brand)}.bg-gradient-nav-item{background:radial-gradient(226.61% 81.19% at 31.88% 51.06%,#780032 0,#0f0d0d);background:var(--c-gradient-nav-item)}.bg-gradient-nav-item-cidp{background:radial-gradient(226.61% 81.19% at 31.88% 51.06%,#174a7c 0,#020e1a);background:var(--c-gradient-nav-item-cidp)}.bg-gradient-dark-brand{background:linear-gradient(159deg,#42001c 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(max-width:1365px){.no-rounded-tablet{border-radius:0}}@media(min-width:1366px)and (max-width:1679px){.no-rounded-desktop{border-radius:0}}.no-border{border:0}@font-face{font-family:Montserrat;src:url(/fonts/montserrat-variable.ttf) format("truetype-variations");font-weight:100 900;font-style:normal;font-display:swap}@font-face{font-family:Montserrat;src:url(/fonts/montserrat-variable-italic.ttf) format("truetype-variations");font-weight:100 900;font-style:italic;font-display:swap}@font-face{font-family:AbrilFatFace;src:url(/fonts/AbrilFatface-Regular.ttf);font-weight:400;font-style:normal;font-display:swap}@font-face{font-family:BebasNeue;src:url(/fonts/BebasNeue-Regular.ttf);font-weight:400;font-style:normal;font-display:swap}@font-face{font-family:Roboto Condensed;src:url(/fonts/RobotoCondensed-Bold.ttf);font-weight:400;font-style:normal;font-display:swap}:root{--ff-montserrat:Montserrat, Arial, sans-serif;--ff-abril:AbrilFatFace, serif;--ff-bebas:BebasNeue, Arial, 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(max-width:1365px){:root{--fs-h3:3.2rem}}@media(max-width:767px){:root{--fs-h3:2.8rem}}:root{--fs-h4:2.4rem}@media(min-width:768px)and (max-width:1365px){:root{--fs-h4:2.4rem}}@media(max-width:767px){:root{--fs-h4:2.2rem}}:root{--fs-h4-desktop:2.4rem;--fs-h5:2.2rem}@media(min-width:768px)and (max-width:1365px){:root{--fs-h5:2.2rem}}@media(max-width:767px){:root{--fs-h5:2rem}}:root{--fs-h6:2rem}@media(min-width:768px)and (max-width:1365px){:root{--fs-h6:2rem}}@media(max-width:767px){:root{--fs-h6:1.8rem}}:root{--fs-eyebrow:1.6rem;--fs-body-large:2rem}@media(min-width:768px)and (max-width:1365px){:root{--fs-body-large:2rem}}@media(max-width:767px){:root{--fs-body-large:1.6rem}}:root{--fs-body-large-mobile:1.8rem;--fs-body-small:1.6rem}@media(min-width:768px)and (max-width:1365px){:root{--fs-body-small:1.6rem}}@media(max-width:767px){:root{--fs-body-small:1.4rem}}:root{--fs-quote:2rem}@media(min-width:768px)and 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.icon{--icon-width:18px}.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):after,.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):before,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):after,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):before{content:"";display:block;position:absolute;left:0;top:0;width:100%;height:100%}.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):before,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):before{z-index:-2;background:var(--button-hover-bg)}.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):active:before,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):active:before{background:var(--button-active-bg)}.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):after,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):after{background:var(--button-bg);opacity:1;transition:opacity 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:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):not(:disabled):after{opacity:0}.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):focus-visible:not(:disabled):after,.button:not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):hover:not(:disabled):after,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):focus-visible:not(:disabled):after,:where(.button.primary):not(.circle-icon.large.icon-only):not(.glass-bg):not(.glass-bg-alt):hover:not(:disabled):after{opacity:0}.button.secondary{--button-bg:var(--c-white);--button-hover-bg:var(--c-brand-50);--button-color:var(--c-black);--button-hover-color:var(--button-color);--button-border-color:var(--c-gray-warm-500);--button-hover-border-color:var(--button-hover-bg);--button-active-bg:var(--button-bg);--button-active-color:var(--button-color);--icon-color:var(--c-brand-500);box-shadow:0 1px 2px 0 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:deep(svg){transform:translateY(7%)}.button.glass-bg-alt{backdrop-filter:blur(3px);--button-bg:linear-gradient(180deg, hsla(0,1%,48%,.04), rgba(62,61,61,.12));border-left:1px solid hsla(0,0%,100%,.5);border-top:1px solid hsla(0,0%,100%,.5);border-bottom:1px solid hsla(0,0%,100%,.3)}.button.circle-icon{--button-radius:50%;--padding-inline:.6rem;--padding-block:.6rem;--icon-size:3.6rem}.button.circle-icon,.button.circle-icon.large.icon-only{--padding-inline:1.4rem;--padding-block:1.4rem;--padding:var(--padding-block) 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.icon{--icon-width:18px}.button.text.white{--button-color:var(--c-white);--button-hover-color:var(--c-brand-100);--icon-color:var(--c-white)}.button.text.icon-branded{--icon-color:var(--c-brand-500)}.button.text.icon-orange,.button.text.icon-yellow{--icon-color:var(--c-orange-500)}.button.text.branded{--button-color:var(--c-brand-500);--button-hover-color:var(--c-brand-900);--icon-color:var(--c-brand-500)}.button.text.block{display:block}.button.text:disabled{background-color:var(--c-transparent)}.button.text:hover:not(:disabled){--icon-color:var(--button-hover-color)}.button.text.underlined{-webkit-text-decoration:underline;text-decoration:underline}.button.small{--button-padding:var(--sp-lg) var(--sp-3xl)}:where(.button.medium){--button-padding:1.2rem 2.2rem}:where(.button.medium).text{--button-padding:0}:where(.button.medium).icon-only:not(.circle-icon){padding:1.2rem 1.4rem}.button.large{--button-padding:1.6rem 3.2rem}.button.large.text{--button-padding:0 .8rem}.button.large.icon-only{padding:1.6rem 1.8rem}.button.connect{border-radius:var(--sp-5xl);--button-color:var(--c-white);--button-border-color:var(--c-yellow);--button-border-width:2px;--button-bg:var(--c-button-brand);--icon-color:var(--c-white);--button-gap:var(--sp-md)}.button.connect.small{font-size:var(--fs-xs);line-height:1;font-weight:var(--fw-bold);--button-padding:var(--sp-2xl) var(--sp-5xl)}.button.connect .icon{--icon-width:9px}.button.connect svg,.button.connect svg path{fill:var(--icon-color)!important;stroke:none!important}.hizentra-product-identification .hizentra-logo[data-v-b1f93958]{height:auto}.hizentra-product-identification p[data-v-b1f93958]{font-size:1.4rem;line-height:1.8rem;padding-top:8px;margin-top:0}@media(max-width:767px){.hizentra-product-identification .hizentra-logo[data-v-b1f93958]{padding-bottom:var(--sp-5xl)}}.isi-heading[data-v-b017a55d]{font-size:18px;line-height:22px}.link[data-v-b017a55d]{color:var(--c-blue-600)}.isi{--max-width:100%;--bg-color:var(--c-white);--floating-minimized-height:calc(1px*var(--v62d11631));--floating-closed-height:calc(1px*var(--v620a4812));--floating-open-top-offset:calc(1px*var(--v08713625));--floating-z-index:9999;max-width:100%;max-width:var(--max-width);border-top:2px solid var(--c-yellow)}.isi:has(.content-container:not(.floating)){margin-bottom:var(--sp-6xl)}body:has(.navbar.mobile.open) .isi{display:none}.isi-button.button{--size:44px;--icon-color:var(--c-black);--padding:0 !important;width:44px;width:var(--size);height:44px;height:var(--size)}@media(max-width:767px){.isi-button.button{--size:32px}.isi-button.button:has(.maximize){--button-bg:var(--c-white) !important;--button-radius:6px !important;border:1px solid var(--c-gray-warm-500)!important}}.isi-button.button .icon{--icon-width:33px}.isi-button.button .icon.maximize{--icon-width:17px}.isi-button.button .icon.chevron-up{transform:translateY(-3%)}.isi-button.button .icon.chevron-down{transform:translateY(3%)}@media(max-width:767px){.isi-button.button .icon{--icon-width:23px}}.isi .content-container{width:100%;background:var(--bg-color);margin-left:auto;margin-right:auto;padding-top:var(--sp-5xl);padding-bottom:var(--sp-6xl)}@media(max-width:767px){.isi .content-container{padding-top:12px!important}}.isi .content-container .button-container{gap:12px;justify-content:flex-end;position:absolute;top:var(--sp-xl);right:var(--sp-2xl)}@media(max-width:767px){.isi .content-container .button-container{right:0}}.isi .content-container .isi-content{width:100%;max-width:var(--content-max-width);margin-left:auto;margin-right:auto}@media(max-width:767px){.isi .content-container .isi-content h4{padding-right:40px}}.isi .content-container .isi-content a,.isi .content-container .isi-content h4,.isi .content-container .isi-content li,.isi .content-container .isi-content p,.isi .content-container .isi-content strong{font-size:1.8rem;line-height:2.2rem}.isi .content-container .isi-content p{line-height:2.7rem}.isi .content-container .isi-content p,.isi .content-container .isi-content strong{margin:0;padding:12px 0 0}.isi .content-container .isi-content ul{margin:0}.isi .content-container .isi-content ul li{margin-top:12px}.isi .content-container:not(.minimized){border-top:2px solid var(--c-yellow)}.isi .content-container.floating{position:fixed;top:calc(100svh - var(--floating-closed-height));left:50%;translate:-50% 0;z-index:var(--floating-z-index);padding-top:var(--sp-3xl);padding-bottom:var(--sp-6xl);height:100svh;width:100%;background:var(--bg-color);box-shadow:0 0 9px #0000001a;transition:top .6s,height .6s}.isi .content-container.floating.minimized{top:calc(100svh - var(--floating-minimized-height))}.isi 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.entry-modal-btns{display:flex;flex-direction:column;gap:1rem;align-items:center}@media(min-width:768px){.entry-modal .entry-modal-btns{gap:3rem;justify-content:center;flex-direction:row}}.entry-modal .entry-modal-btns a,.entry-modal .entry-modal-btns button{width:160px!important}.hamburger-menu-button[data-v-d57b7897]{--size:48px;--line-size:18px;--line-width:33px;cursor:pointer;background:transparent;border:none;padding:0;width:48px;width:var(--size);height:48px;height:var(--size);display:grid;align-items:center;justify-items:center;place-items:center}.hamburger-menu-button .hamburger-icon[data-v-d57b7897]{height:var(--line-size);width:var(--line-width);position:relative}.hamburger-menu-button .hamburger-icon .line[data-v-d57b7897]{height:3px;width:100%;background-color:var(--c-white);border-radius:3px;position:absolute;transition:top .4s,transform .4s,opacity .2s;right:0}.hamburger-menu-button .hamburger-icon .line[data-v-d57b7897]:first-child{top:0}.hamburger-menu-button 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(max-width:1600px){.button.nav-item{--button-font-size:max(1rem, min(.85vw, 1.4rem))}}.button.nav-item .button-content{justify-content:normal;grid-template-columns:1fr auto}.button.nav-item .button-label{width:100%}.button.nav-item.nav-link{--button-hover-color:var(--c-brand-900);--button-active-color:var(--c-brand-900);--button-hover-bg:transparent}.button.nav-item.nav-link .icon{--icon-width:16px}.navbar-wrapper.nav-bg-dark .main-nav-items .button.nav-item.nav-link{--button-hover-bg:transparent}.navbar-wrapper.nav-bg-dark .main-nav-items .button.nav-item.nav-link:not(.topnav-item){--button-color:var(--c-white);--button-hover-color:var(--c-white)}.button.nav-item.nav-link.mobile{--button-hover-color:var(--c-blue-900) !important;--button-color:var(--c-blue-900) !important;--button-active-color:var(--c-blue-900) 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.icon{background:var(--c-yellow)}.references:not(.unstyled):not([class*=mt-]):not([class*=mtb-]){margin-top:var(--sp-2xl)}@media(max-width:767px){.references:not(.unstyled):not([class*=mt-]):not([class*=mtb-]){margin-top:var(--sp-md)}}.page-layout>section>.references:last-child{margin-bottom:var(--sp-4xl)}.references .ref{--default-text-margin:1rem}.references .ref.joined{line-height:1.8rem}.references.hang .hang{position:relative;left:-1px}.references.hang .ref sup:first-child{--size:.7;--chars:1;--font-size:calc(100%*var(--size));--hang-amount:calc(var(--size)*-1*(var(--chars)*1ch));line-height:1;font-size:70%;font-size:var(--font-size);color:currentColor;margin-left:-.7ch;margin-left:var(--hang-amount)}.references.hang .ref sup:first-child.asterisk{--size:1;--chars:.55;vertical-align:text-top}.references .ref sup:first-child.asterisk{font-size:90%;vertical-align:text-top}.abbreviations[data-v-eb0ec040]:not([class*=mt-]):not([class*=mtb-]){margin-top:var(--sp-4xl)}@media(max-width:767px){.abbreviations[data-v-eb0ec040]:not([class*=mt-]):not([class*=mtb-]){margin-top:var(--sp-md)}}.abbreviations[data-v-eb0ec040]:last-child{margin-bottom:var(--sp-4xl)}.demoted-heading{font-size:20px;line-height:22px}.indication-modal{border:none;width:calc(100% - var(--sp-8xl));max-width:1300px;padding:0;z-index:999;background:none;top:90px;margin-top:0;margin-bottom:0;max-height:none;overflow:visible}@media(min-width:1300px){.indication-modal{top:90px}}.indication-modal h4{font-size:20px}.indication-modal::backdrop{background:#000000b8}.indication-modal .close-button{position:absolute;right:calc(var(--sp-2xl) + 10px);top:var(--sp-2xl);--icon-color:var(--c-blue-900);--button-hover-bg:var(--c-white);--padding-inline:5px !important;--padding-block:5px !important}.indication-modal .splitter-modal__inner,.indication-modal__inner{width:100%;max-height:calc(100dvh - 290px);overflow:auto;border-radius:6px}@media(min-width:991px){.indication-modal .modal-heading{font-size:52px}}.indication-modal .hizentra-connect{display:flex;width:100%;align-items:center;justify-content:center}.indication-modal .hizentra-connect svg{max-width:100%;height:auto}.indication-modal .hizentra-logo-wrapper{height:0;transform:translate(-4.4rem,-6.4rem)}@media(max-width:767px){.indication-modal .hizentra-logo-wrapper{transform:translate(-1rem,-8rem)}}.indication-modal .logo-container{width:178px;height:auto}@media(max-width:990px){.indication-modal .logo-container{width:96px;padding:10px 11px!important}}.skip-link{position:absolute;top:0;left:0;z-index:1000;padding:.75rem 1.25rem;background:#144a7d;background:var(--color-blue-500,#144a7d);color:#fff;font-weight:600;-webkit-text-decoration:underline;text-decoration:underline;transform:translateY(-100%)}.skip-link:focus{transform:translateY(0)}@media(prefers-reduced-motion:no-preference){.skip-link{transition:transform .15s ease-out}}#main-content:focus{outline:none}@media(max-width:767px){body:not(:has(.indication-modal)) .page-layout{margin-top:-60px}}